The Resource Applied pharmacometrics, Stephan Schmidt, Hartmut Derendorf, editors

Applied pharmacometrics, Stephan Schmidt, Hartmut Derendorf, editors

Label
Applied pharmacometrics
Title
Applied pharmacometrics
Statement of responsibility
Stephan Schmidt, Hartmut Derendorf, editors
Contributor
Subject
Genre
Language
eng
Summary
This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer?s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success
Member of
Cataloging source
N$T
Dewey number
615/.1
Index
index present
LC call number
RS187
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 744
http://library.link/vocab/relatedWorkOrContributorName
  • Schmidt, Stephan
  • Derendorf, Hartmut
Series statement
AAPS advances in the pharmaceutical sciences series
Series volume
14
http://library.link/vocab/subjectName
  • Pharmacology
  • Pharmacokinetics
  • MEDICAL
  • Pharmacokinetics
  • Pharmacology
  • Chemistry, Pharmaceutical
  • Biomedicine
  • Pharmaceutical Sciences/Technology
Label
Applied pharmacometrics, Stephan Schmidt, Hartmut Derendorf, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-1304-6
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics -- 2 Personalized Medicine? Integrating Individual Exposure and Response Information at the Bedside -- 3 Pharmacometrics in Pediatrics -- 4 Pharmacometrics in Chronic Kidney Disease -- 5 Drug-Disease Model-Based Development of Therapeutic Agents for Treatment of Diabetes -- 6 Applied Pharmacometrics in the Obese Population -- 7 Pharmacometrics in Cardiovascular Safety -- 8 Pharmacometrics in Bacterial Infections -- 9 Pharmacometrics in Viral Infections -- 10 Applied Antifungal Pharmacometrics: Fluconazole and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis -- 11 Pharmacometrics and Tuberculosis -- 12 Pharmacometrics in Pulmonary Diseases -- 13 State-of-the-Art Pharmacometric Models in Osteoporosis -- 14 Pharmacometrics in Psychiatric Diseases -- 15 Clinical Trial Simulation in Alzheimer?s Disease -- 16 Pharmacometric Applications in Inflammation -- 17 Pharmacometrics in Dermatology -- 18 Pharmacometrics in Pain Management -- 19 Pharmacometrics of Hyperlipidemia
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781493913046
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-1-4939-1304-6
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)897466424
  • (OCoLC)ocn897466424
Label
Applied pharmacometrics, Stephan Schmidt, Hartmut Derendorf, editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-1304-6
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics -- 2 Personalized Medicine? Integrating Individual Exposure and Response Information at the Bedside -- 3 Pharmacometrics in Pediatrics -- 4 Pharmacometrics in Chronic Kidney Disease -- 5 Drug-Disease Model-Based Development of Therapeutic Agents for Treatment of Diabetes -- 6 Applied Pharmacometrics in the Obese Population -- 7 Pharmacometrics in Cardiovascular Safety -- 8 Pharmacometrics in Bacterial Infections -- 9 Pharmacometrics in Viral Infections -- 10 Applied Antifungal Pharmacometrics: Fluconazole and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis -- 11 Pharmacometrics and Tuberculosis -- 12 Pharmacometrics in Pulmonary Diseases -- 13 State-of-the-Art Pharmacometric Models in Osteoporosis -- 14 Pharmacometrics in Psychiatric Diseases -- 15 Clinical Trial Simulation in Alzheimer?s Disease -- 16 Pharmacometric Applications in Inflammation -- 17 Pharmacometrics in Dermatology -- 18 Pharmacometrics in Pain Management -- 19 Pharmacometrics of Hyperlipidemia
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9781493913046
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-1-4939-1304-6
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)897466424
  • (OCoLC)ocn897466424

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