The Resource Antibody-Drug Conjugates, edited by Laurent Ducry, (electronic resource)

Antibody-Drug Conjugates, edited by Laurent Ducry, (electronic resource)

Label
Antibody-Drug Conjugates
Title
Antibody-Drug Conjugates
Statement of responsibility
edited by Laurent Ducry
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future
Member of
Dewey number
615.3/7
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
OpcP5Awi3OE
Image bit depth
0
Language note
English
LC call number
RM1-950
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
Ducry, Laurent.
Series statement
Methods in Molecular Biology,
Series volume
1045
http://library.link/vocab/subjectName
  • Toxicology
  • Oncology
  • Pharmacology/Toxicology
  • Oncology
Label
Antibody-Drug Conjugates, edited by Laurent Ducry, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review -- Antibody-Drug Conjugate Target Selection: Critical Factors -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization -- Antibody-Drug Conjugate Payloads -- Linker Technologies for Antibody-Drug Conjugates -- In Vivo Testing of Drug-Linker Stability -- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates -- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment -- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting -- Protocols for Lysine Conjugation -- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers -- Enzymatic Antibody Modification by Bacterial Transglutaminase -- Formulation Development of Antibody-Drug Conjugates -- Conjugation Process Development and Scale-Up -- Methods for Conjugating Antibodies to Nanocarriers -- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS -- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF -- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (X, 317 p. 96 illus., 42 illus. in color.)
File format
multiple file formats
Form of item
online
Isbn
9781627035415
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-62703-541-5
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3280000000033932
  • (SSID)ssj0001065037
  • (PQKBManifestationID)12417282
  • (PQKBTitleCode)TC0001065037
  • (PQKBWorkID)11059936
  • (PQKB)11580883
  • (DE-He213)978-1-62703-541-5
  • (EXLCZ)993280000000033932
Label
Antibody-Drug Conjugates, edited by Laurent Ducry, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Color
not applicable
Content category
text
Content type code
txt
Contents
Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review -- Antibody-Drug Conjugate Target Selection: Critical Factors -- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization -- Antibody-Drug Conjugate Payloads -- Linker Technologies for Antibody-Drug Conjugates -- In Vivo Testing of Drug-Linker Stability -- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates -- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment -- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting -- Protocols for Lysine Conjugation -- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers -- Enzymatic Antibody Modification by Bacterial Transglutaminase -- Formulation Development of Antibody-Drug Conjugates -- Conjugation Process Development and Scale-Up -- Methods for Conjugating Antibodies to Nanocarriers -- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography -- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS -- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF -- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs)
Dimensions
unknown
Edition
1st ed. 2013.
Extent
1 online resource (X, 317 p. 96 illus., 42 illus. in color.)
File format
multiple file formats
Form of item
online
Isbn
9781627035415
Level of compression
uncompressed
Media category
computer
Media type code
c
Other control number
10.1007/978-1-62703-541-5
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)3280000000033932
  • (SSID)ssj0001065037
  • (PQKBManifestationID)12417282
  • (PQKBTitleCode)TC0001065037
  • (PQKBWorkID)11059936
  • (PQKB)11580883
  • (DE-He213)978-1-62703-541-5
  • (EXLCZ)993280000000033932

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