The Resource Animal models of ophthalmic diseases, Chi-Chao Chan, editor

Animal models of ophthalmic diseases, Chi-Chao Chan, editor

Label
Animal models of ophthalmic diseases
Title
Animal models of ophthalmic diseases
Statement of responsibility
Chi-Chao Chan, editor
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves? disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience, and the text is supported by numerous photos and diagrams. Development of suitable experimental models is critical in identifying risk factors for disease, elucidating fundamental molecular mechanisms in disease progression, and providing guidance as to whether or not a particular treatment is safe and effective for humans. Like other forms of medical research, ophthalmology and vision research focuses on the investigation of disease pathogenesis and the discovery of novel therapies through in vitro and in vivo methodology. The in vivo experiments employ animal models including vertebrates (zebrafish, rodents, rabbits, and primates) and invertebrates (fruit flies and nematodes) for drug screening. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents, and medical students
Member of
Cataloging source
N$T
Dewey number
617.7/1
Index
index present
LC call number
RE48
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
WW 140
http://library.link/vocab/relatedWorkOrContributorName
Chan, Chi-Chao
Series statement
Essentials in ophthalmology
http://library.link/vocab/subjectName
  • Eye
  • Medicine & Public Health
  • Ophthalmology
  • Animal Models
Label
Animal models of ophthalmic diseases, Chi-Chao Chan, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-19434-9
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Contents; Contributors; Chapter-1; Animal Models of Herpes Keratitis; 1.1 Introduction to Herpes Keratitis ; 1.2 HSV-1 Latency ; 1.3 HSV-1 Keratitis ; 1.3.1 HSV-1 Epithelial Keratitis; 1.3.2 Herpes Stromal Keratitis; 1.3.2.1 Neurotrophic Damage as a Major Component of HSK in Mice; 1.4 Allografts on Corneas with HSK ; References; Commentary; References; Chapter-2; Animal Models of Cataracts; 2.1 Introduction; 2.2 Models of Congenital Cataract; 2.2.1 Crystallins; 2.2.2 Connexins; 2.2.3 Cytoskeletal and Membrane Proteins; 2.3 Models of Age-Related Cataracts
  • 2.3.1 Diabetic Cataract2.3.2 UV-Induced Cataracts; 2.3.3 Steroid-Induced Cataracts; 2.3.4 Oxygen and Nuclear Cataracts; 2.4 Secondary Cataract; 2.5 Conclusion; References; Commentary; Chapter-3; Animal Models of Glaucoma; 3.1 Introduction; 3.2 Rodent Glaucoma Models; 3.3 Episcleral Vein Injection/Ablation; 3.4 Translimbal Laser Photocoagulation; 3.5 Microbead Injection; 3.6 Other Models of Induced Ocular Hypertension; 3.7 Genetic Mouse and Rat Models; 3.8 Primary Open-Angle Glaucoma Models; 3.9 Primary Angle-Closure Glaucoma Models; 3.10 Pigmentary Dispersion and Exfoliation Glaucoma Models
  • 3.11 Congenital and Developmental Glaucoma Models3.12 Future Possible Models; 3.13 Conclusions; References; Commentary; Chapter-4; Animal Models of Age-Related Macular Degeneration: Subretinal Inflammation; 4.1 Introduction; 4.2 Inflammation and Age-Related Macular Degeneration; 4.3 Subretinal Inflammation in AMD Animal Models ; 4.3.1 AMD-Associated Risk Factors and Inflammation; 4.3.1.1 Genetic Risk Factors; 4.3.1.2 AMD-Associated Environmental Risk Factors and Inflammation; 4.3.2.1 Suppression of Tonic Anti-Inflammatory Signals; 4.3.2.2 Defective Immunosuppressive Environment
  • 4.3.2.3 Autoimmune Reaction4.3.3 "Secondary inflammation" AMD Models; 4.4 Conclusion; References; Commentary; Commentary; Chapter-5; Animal Models of Diabetic Retinopathy; 5.1 Introduction and Clinical Context; 5.2 The Need for Animal Models to Understand the Pathophysiology of DR; 5.3 Rodent Models of DR; 5.3.1 Chemically Induced Diabetes in Mice and Rats; 5.3.2 Spontaneous Diabetic Rodents as Models of DR; 5.3.3 Diet-Induced DR in Rodents; 5.4 Dog Models of DR; 5.5 Other Large Animals of DR; 5.6 Non-mammalian Models of DR; 5.7 Models of PDR; 5.7.1 VEGF Overexpression
  • 5.7.2 Oxygen-Induced Retinopathy5.8 Techniques to Detect Retinal Lesion in Animal Models of Diabetes; 5.8.1 Fundus Colour Imaging; 5.8.2 Confocal Scanning Laser Ophthalmoscope (cSLO); 5.8.3 Optical Coherence Tomography (OCT); 5.8.4 Electroretinogarphy (ERG); 5.9 Conclusion; References; Commentary; Chapter-6; Animal Models of autoimmune uveitis; 6.1 Introduction; 6.2 Why Do We Need Animal Models to Study Human Uveitis?; 6.3 Animal Models of Uveitis Exhibit Clinical Heterogeneity, Similar to Human Uveitis; 6.4 Induced Animal Models of Uveitis; 6.4.1 Experimental Autoimmune Uveitis (EAU)
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319194349
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-19434-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)931533657
  • (OCoLC)ocn931533657
Label
Animal models of ophthalmic diseases, Chi-Chao Chan, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-19434-9
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Foreword; Preface; Contents; Contributors; Chapter-1; Animal Models of Herpes Keratitis; 1.1 Introduction to Herpes Keratitis ; 1.2 HSV-1 Latency ; 1.3 HSV-1 Keratitis ; 1.3.1 HSV-1 Epithelial Keratitis; 1.3.2 Herpes Stromal Keratitis; 1.3.2.1 Neurotrophic Damage as a Major Component of HSK in Mice; 1.4 Allografts on Corneas with HSK ; References; Commentary; References; Chapter-2; Animal Models of Cataracts; 2.1 Introduction; 2.2 Models of Congenital Cataract; 2.2.1 Crystallins; 2.2.2 Connexins; 2.2.3 Cytoskeletal and Membrane Proteins; 2.3 Models of Age-Related Cataracts
  • 2.3.1 Diabetic Cataract2.3.2 UV-Induced Cataracts; 2.3.3 Steroid-Induced Cataracts; 2.3.4 Oxygen and Nuclear Cataracts; 2.4 Secondary Cataract; 2.5 Conclusion; References; Commentary; Chapter-3; Animal Models of Glaucoma; 3.1 Introduction; 3.2 Rodent Glaucoma Models; 3.3 Episcleral Vein Injection/Ablation; 3.4 Translimbal Laser Photocoagulation; 3.5 Microbead Injection; 3.6 Other Models of Induced Ocular Hypertension; 3.7 Genetic Mouse and Rat Models; 3.8 Primary Open-Angle Glaucoma Models; 3.9 Primary Angle-Closure Glaucoma Models; 3.10 Pigmentary Dispersion and Exfoliation Glaucoma Models
  • 3.11 Congenital and Developmental Glaucoma Models3.12 Future Possible Models; 3.13 Conclusions; References; Commentary; Chapter-4; Animal Models of Age-Related Macular Degeneration: Subretinal Inflammation; 4.1 Introduction; 4.2 Inflammation and Age-Related Macular Degeneration; 4.3 Subretinal Inflammation in AMD Animal Models ; 4.3.1 AMD-Associated Risk Factors and Inflammation; 4.3.1.1 Genetic Risk Factors; 4.3.1.2 AMD-Associated Environmental Risk Factors and Inflammation; 4.3.2.1 Suppression of Tonic Anti-Inflammatory Signals; 4.3.2.2 Defective Immunosuppressive Environment
  • 4.3.2.3 Autoimmune Reaction4.3.3 "Secondary inflammation" AMD Models; 4.4 Conclusion; References; Commentary; Commentary; Chapter-5; Animal Models of Diabetic Retinopathy; 5.1 Introduction and Clinical Context; 5.2 The Need for Animal Models to Understand the Pathophysiology of DR; 5.3 Rodent Models of DR; 5.3.1 Chemically Induced Diabetes in Mice and Rats; 5.3.2 Spontaneous Diabetic Rodents as Models of DR; 5.3.3 Diet-Induced DR in Rodents; 5.4 Dog Models of DR; 5.5 Other Large Animals of DR; 5.6 Non-mammalian Models of DR; 5.7 Models of PDR; 5.7.1 VEGF Overexpression
  • 5.7.2 Oxygen-Induced Retinopathy5.8 Techniques to Detect Retinal Lesion in Animal Models of Diabetes; 5.8.1 Fundus Colour Imaging; 5.8.2 Confocal Scanning Laser Ophthalmoscope (cSLO); 5.8.3 Optical Coherence Tomography (OCT); 5.8.4 Electroretinogarphy (ERG); 5.9 Conclusion; References; Commentary; Chapter-6; Animal Models of autoimmune uveitis; 6.1 Introduction; 6.2 Why Do We Need Animal Models to Study Human Uveitis?; 6.3 Animal Models of Uveitis Exhibit Clinical Heterogeneity, Similar to Human Uveitis; 6.4 Induced Animal Models of Uveitis; 6.4.1 Experimental Autoimmune Uveitis (EAU)
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319194349
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-19434-9
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)931533657
  • (OCoLC)ocn931533657

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