The Resource Androgen Action in Prostate Cancer, edited by James Mohler, Donald Tindall, (electronic resource)

Androgen Action in Prostate Cancer, edited by James Mohler, Donald Tindall, (electronic resource)

Label
Androgen Action in Prostate Cancer
Title
Androgen Action in Prostate Cancer
Statement of responsibility
edited by James Mohler, Donald Tindall
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800’s, and then awareness reawakened in the 1940’s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer
Dewey number
616.99463
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
  • 7zLiag0UeVg
  • W8TKpM5ERGk
Language note
English
LC call number
RC261-271
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Mohler, James.
  • Tindall, Donald.
http://library.link/vocab/subjectName
  • Oncology
  • Human genetics
  • Microbiology
  • Toxicology
  • Immunology
  • Medical virology
  • Cancer Research
  • Human Genetics
  • Medical Microbiology
  • Pharmacology/Toxicology
  • Immunology
  • Virology
Label
Androgen Action in Prostate Cancer, edited by James Mohler, Donald Tindall, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer -- Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Historical Perspective -- Clinical Progression to Castration-Recurrent Prostate Cancer -- Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression -- Imaging Androgen Receptor Function In Vivo -- Androgen Metabolism -- Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer -- Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression -- Effect of Steroid 5?-Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer -- 5?-Reductase Isozymes in Castration-Recurrent Prostate Cancer -- Improving Intermittent Androgen-Deprivation Therapy: OFF Cycle and the Role of Steroid 5?-Reductase Inhibitors -- Androgen Receptor Structure/Function Relationships -- Insights from AR Gene Mutations -- Functional Motifs of the Androgen Receptor -- The Role of the Androgen Receptor Polyglutamine Tract in Prostate Cancer: In Mice and Men -- The Androgen Receptor Coactivator-Binding Interface -- Co-Regulators of the Androgen Receptor -- Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer -- Androgen Receptor Coregulators and Their Role in Prostate Cancer -- Interaction of the Androgen Receptor Ligand-Binding Domain with the N-Terminal Domain and with Coactivators -- Multitasking and Interplay Between the Androgen Receptor Domains -- Chromatin Remodeling and Androgen Receptor-Mediated Transcription -- Ligand-Independent Activation of the Androgen Receptor -- Ligand-Independent Androgen Receptor Activity -- Role of IL-6 in Regulating the Androgen Receptor -- The Role of Cyclic AMP in Regulating the Androgen Receptor -- Role of the Androgen Receptor in Prostate Cancer during Castration -- Cellular and Molecular Signatures of Androgen Ablation of Prostate Cancer -- Tissue Levels of Androgens in Castration-Recurrent Prostate Cancer -- Unique Effects of Wnt Signaling on Prostate Cancer Cells: Modulation of the Androgen Signaling Pathway by Interactions of the Androgen Receptor Gene and Protein with Key Components of the Canonical Wnt Signaling Pathway -- The Role of Foxa Proteins in the Regulation of Androgen Receptor Activity -- Androgen-Regulated Genes during Prostate Cancer Progression -- Androgen Receptor as a Licensing Factor for DNA Replication -- Androgen-Regulated Genes in the Prostate -- Mapping the Androgen Receptor Cistrome -- Differential Regulation of Clusterin Isoforms by the Androgen Receptor -- Androgen Regulation of Prostate Cancer Gene Fusions -- Androgens and the Lipogenic Switch in Prostate Cancer -- The Androgen Receptor as a Drugable Target -- Molecular Biology of Novel Targets Identified Through Study of Castration-Recurrent Prostate Cancer -- Selenium and Androgen Receptor in Prostate Cancer
Dimensions
unknown
Extent
1 online resource (781 p.)
Form of item
online
Isbn
9781282126510
Media category
computer
Media type code
c
Other control number
10.1007/978-0-387-69179-4
Specific material designation
remote
System control number
  • (CKB)1000000000746323
  • (EBL)438060
  • (OCoLC)405547043
  • (SSID)ssj0000103420
  • (PQKBManifestationID)11128490
  • (PQKBTitleCode)TC0000103420
  • (PQKBWorkID)10069847
  • (PQKB)10038527
  • (DE-He213)978-0-387-69179-4
  • (MiAaPQ)EBC438060
  • (EXLCZ)991000000000746323
Label
Androgen Action in Prostate Cancer, edited by James Mohler, Donald Tindall, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer -- Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Historical Perspective -- Clinical Progression to Castration-Recurrent Prostate Cancer -- Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression -- Imaging Androgen Receptor Function In Vivo -- Androgen Metabolism -- Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer -- Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression -- Effect of Steroid 5?-Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer -- 5?-Reductase Isozymes in Castration-Recurrent Prostate Cancer -- Improving Intermittent Androgen-Deprivation Therapy: OFF Cycle and the Role of Steroid 5?-Reductase Inhibitors -- Androgen Receptor Structure/Function Relationships -- Insights from AR Gene Mutations -- Functional Motifs of the Androgen Receptor -- The Role of the Androgen Receptor Polyglutamine Tract in Prostate Cancer: In Mice and Men -- The Androgen Receptor Coactivator-Binding Interface -- Co-Regulators of the Androgen Receptor -- Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer -- Androgen Receptor Coregulators and Their Role in Prostate Cancer -- Interaction of the Androgen Receptor Ligand-Binding Domain with the N-Terminal Domain and with Coactivators -- Multitasking and Interplay Between the Androgen Receptor Domains -- Chromatin Remodeling and Androgen Receptor-Mediated Transcription -- Ligand-Independent Activation of the Androgen Receptor -- Ligand-Independent Androgen Receptor Activity -- Role of IL-6 in Regulating the Androgen Receptor -- The Role of Cyclic AMP in Regulating the Androgen Receptor -- Role of the Androgen Receptor in Prostate Cancer during Castration -- Cellular and Molecular Signatures of Androgen Ablation of Prostate Cancer -- Tissue Levels of Androgens in Castration-Recurrent Prostate Cancer -- Unique Effects of Wnt Signaling on Prostate Cancer Cells: Modulation of the Androgen Signaling Pathway by Interactions of the Androgen Receptor Gene and Protein with Key Components of the Canonical Wnt Signaling Pathway -- The Role of Foxa Proteins in the Regulation of Androgen Receptor Activity -- Androgen-Regulated Genes during Prostate Cancer Progression -- Androgen Receptor as a Licensing Factor for DNA Replication -- Androgen-Regulated Genes in the Prostate -- Mapping the Androgen Receptor Cistrome -- Differential Regulation of Clusterin Isoforms by the Androgen Receptor -- Androgen Regulation of Prostate Cancer Gene Fusions -- Androgens and the Lipogenic Switch in Prostate Cancer -- The Androgen Receptor as a Drugable Target -- Molecular Biology of Novel Targets Identified Through Study of Castration-Recurrent Prostate Cancer -- Selenium and Androgen Receptor in Prostate Cancer
Dimensions
unknown
Extent
1 online resource (781 p.)
Form of item
online
Isbn
9781282126510
Media category
computer
Media type code
c
Other control number
10.1007/978-0-387-69179-4
Specific material designation
remote
System control number
  • (CKB)1000000000746323
  • (EBL)438060
  • (OCoLC)405547043
  • (SSID)ssj0000103420
  • (PQKBManifestationID)11128490
  • (PQKBTitleCode)TC0000103420
  • (PQKBWorkID)10069847
  • (PQKB)10038527
  • (DE-He213)978-0-387-69179-4
  • (MiAaPQ)EBC438060
  • (EXLCZ)991000000000746323

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