The Resource Amorphous solid dispersions : theory and practice, Navnit Shah [and 4 more], editors

Amorphous solid dispersions : theory and practice, Navnit Shah [and 4 more], editors

Label
Amorphous solid dispersions : theory and practice
Title
Amorphous solid dispersions
Title remainder
theory and practice
Statement of responsibility
Navnit Shah [and 4 more], editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future
Member of
Cataloging source
N$T
Dewey number
615.7
Illustrations
illustrations
Index
index present
LC call number
RM301.5
Literary form
non fiction
Nature of contents
dictionaries
NLM call number
QV 778
http://library.link/vocab/relatedWorkOrContributorName
Shah, Navnit
Series statement
Advances in delivery science and technology
http://library.link/vocab/subjectName
  • Polymers
  • Pharmaceutical technology
  • Absorption
  • Polymers
  • Solubility
  • MEDICAL
  • Absorption
  • Pharmaceutical technology
  • Solubility
  • Biomedicine
  • Pharmaceutical Sciences/Technology
  • Chemistry, Pharmaceutical
Label
Amorphous solid dispersions : theory and practice, Navnit Shah [and 4 more], editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-1598-9
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Fundamentals of Amorphous Systems: Thermodynamic Aspects -- 2 Theoretical Considerations in Developing Amorphous Solid Dispersions -- 3 Overview of Amorphous Solid Dispersion Technologies -- 4 Excipients for Amorphous Solid Dispersions -- 5 Miniaturized Screening Tools for Polymer and Process Evaluation -- 6 HME for Solid Dispersions: Composition and Design Considerations -- 7 HME for Solid Dispersions: Scale up and Late Stage Development -- 8 Spray Drying: Scale UP and Manufacturing -- 9 Design and Development of HPMCAS based spray dried dispersions -- 10 MBP Technology: Composition and Design Considerations -- 11 MBP Technology: Process Development and Scale up -- 12 Pharmaceutical Development of MBP Solid Dispersions: Case Studies -- 13 Downstream Processing Considerations -- 14 Structural Characterization of Amorphous Solid Dispersions -- 15 Dissolution of Amorphous Solid Dispersions: Theory and Practice -- 16 Stability of Amorphous Solid Dispersion -- 17 Regulatory Considerations in Development of Amorphous Solid Dispersions -- 18 KinetiSol® based Amorphous Solid Dispersions -- 19 Amorphous Solid Dispersion Using Supercritical Fluid Technology -- 20 Supersolubilization by Using Non-Salt Forming Acid-Base Interaction -- 21 Stabilized Amorphous Solid Dispersions with Small Molecule Excipients -- 22 Mesoporous ASD? Fundamentals -- 23 Mesoporous Silica Drug Delivery Systems
Dimensions
unknown
Extent
1 online resource (xxii, 699 pages)
File format
unknown
Form of item
online
Isbn
9781493915972
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-1-4939-1598-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)896824888
  • (OCoLC)ocn896824888
Label
Amorphous solid dispersions : theory and practice, Navnit Shah [and 4 more], editors
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-1-4939-1598-9
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1 Fundamentals of Amorphous Systems: Thermodynamic Aspects -- 2 Theoretical Considerations in Developing Amorphous Solid Dispersions -- 3 Overview of Amorphous Solid Dispersion Technologies -- 4 Excipients for Amorphous Solid Dispersions -- 5 Miniaturized Screening Tools for Polymer and Process Evaluation -- 6 HME for Solid Dispersions: Composition and Design Considerations -- 7 HME for Solid Dispersions: Scale up and Late Stage Development -- 8 Spray Drying: Scale UP and Manufacturing -- 9 Design and Development of HPMCAS based spray dried dispersions -- 10 MBP Technology: Composition and Design Considerations -- 11 MBP Technology: Process Development and Scale up -- 12 Pharmaceutical Development of MBP Solid Dispersions: Case Studies -- 13 Downstream Processing Considerations -- 14 Structural Characterization of Amorphous Solid Dispersions -- 15 Dissolution of Amorphous Solid Dispersions: Theory and Practice -- 16 Stability of Amorphous Solid Dispersion -- 17 Regulatory Considerations in Development of Amorphous Solid Dispersions -- 18 KinetiSol® based Amorphous Solid Dispersions -- 19 Amorphous Solid Dispersion Using Supercritical Fluid Technology -- 20 Supersolubilization by Using Non-Salt Forming Acid-Base Interaction -- 21 Stabilized Amorphous Solid Dispersions with Small Molecule Excipients -- 22 Mesoporous ASD? Fundamentals -- 23 Mesoporous Silica Drug Delivery Systems
Dimensions
unknown
Extent
1 online resource (xxii, 699 pages)
File format
unknown
Form of item
online
Isbn
9781493915972
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-1-4939-1598-9
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)896824888
  • (OCoLC)ocn896824888

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