The Resource Alzheimer's Disease and Frontotemporal Dementia : Methods and Protocols, edited by Erik D. Roberson, (electronic resource)

Alzheimer's Disease and Frontotemporal Dementia : Methods and Protocols, edited by Erik D. Roberson, (electronic resource)

Label
Alzheimer's Disease and Frontotemporal Dementia : Methods and Protocols
Title
Alzheimer's Disease and Frontotemporal Dementia
Title remainder
Methods and Protocols
Statement of responsibility
edited by Erik D. Roberson
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders
Member of
Is Subseries of
Dewey number
611.01816
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
GUo8o7xEvrI
Image bit depth
0
Language note
English
LC call number
QH506
Literary form
non fiction
http://library.link/vocab/relatedWorkOrContributorName
Roberson, Erik D.
Series statement
Methods in Molecular Biology,
Series volume
670
http://library.link/vocab/subjectName
  • Medicine
  • Neurology
  • Molecular Medicine
  • Neurology
Label
Alzheimer's Disease and Frontotemporal Dementia : Methods and Protocols, edited by Erik D. Roberson, (electronic resource)
Instantiates
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Color
not applicable
Content category
text
Content type code
  • txt
Contents
Contemporary Approaches to Alzheimer’s Disease and Frontotemporal Dementia -- Preparing Synthetic A in Different Aggregation States -- Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain -- Detecting A*56 Oligomers in Brain Tissues -- Assessing A Aggregation State by Atomic Force Microscopy -- Measuring APP Carboxy-Terminal Fragments -- Detection of APP Intracellular Domain (AICD) in Brain Tissue -- Cell-Based Assays for Regulators of Tau Biology -- Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation In situ -- Apolipoprotein E Expression and Purification -- Aβ Toxicity in Primary Cultured Neurons -- Manipulation of Gene Expression in the Central Nervous System with Lentiviral Vectors -- Selecting a Mouse Model of Alzheimer’s Disease -- Monitoring Spatial Learning and Memory in Alzheimer’s Disease Mouse Models Using the Morris Water Maze -- Step-by-Step In Situ Hybridization Method for Localizing Gene Expression Changes in the Brain -- Real-Time Visualization of Axonal Transport in Neurons -- Quantifying Biomarkers of Cognitive Dysfunction and Neuronal Network Hyperexcitability in Mouse Models of Alzheimer’s Disease: Depletion of Calcium-Dependent Proteins and Inhibitory Hippocampal Remodeling -- Epigenetic Changes in the Brain: Measuring Global Histone Modifications
Dimensions
unknown
Edition
1st ed. 2011.
Extent
1 online resource (X, 270 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607617440
Level of compression
uncompressed
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-60761-744-0
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000057441
  • (SSID)ssj0000448999
  • (PQKBManifestationID)11316065
  • (PQKBTitleCode)TC0000448999
  • (PQKBWorkID)10428225
  • (PQKB)11030992
  • (DE-He213)978-1-60761-744-0
  • (EXLCZ)992670000000057441
Label
Alzheimer's Disease and Frontotemporal Dementia : Methods and Protocols, edited by Erik D. Roberson, (electronic resource)
Publication
Note
Bibliographic Level Mode of Issuance: Monograph
Antecedent source
mixed
Carrier category
online resource
Carrier category code
  • cr
Color
not applicable
Content category
text
Content type code
  • txt
Contents
Contemporary Approaches to Alzheimer’s Disease and Frontotemporal Dementia -- Preparing Synthetic A in Different Aggregation States -- Isolation of Low-n Amyloid β-Protein Oligomers from Cultured Cells, CSF, and Brain -- Detecting A*56 Oligomers in Brain Tissues -- Assessing A Aggregation State by Atomic Force Microscopy -- Measuring APP Carboxy-Terminal Fragments -- Detection of APP Intracellular Domain (AICD) in Brain Tissue -- Cell-Based Assays for Regulators of Tau Biology -- Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation In situ -- Apolipoprotein E Expression and Purification -- Aβ Toxicity in Primary Cultured Neurons -- Manipulation of Gene Expression in the Central Nervous System with Lentiviral Vectors -- Selecting a Mouse Model of Alzheimer’s Disease -- Monitoring Spatial Learning and Memory in Alzheimer’s Disease Mouse Models Using the Morris Water Maze -- Step-by-Step In Situ Hybridization Method for Localizing Gene Expression Changes in the Brain -- Real-Time Visualization of Axonal Transport in Neurons -- Quantifying Biomarkers of Cognitive Dysfunction and Neuronal Network Hyperexcitability in Mouse Models of Alzheimer’s Disease: Depletion of Calcium-Dependent Proteins and Inhibitory Hippocampal Remodeling -- Epigenetic Changes in the Brain: Measuring Global Histone Modifications
Dimensions
unknown
Edition
1st ed. 2011.
Extent
1 online resource (X, 270 p.)
File format
multiple file formats
Form of item
online
Isbn
9781607617440
Level of compression
uncompressed
Media category
computer
Media type code
  • c
Other control number
10.1007/978-1-60761-744-0
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote
System control number
  • (CKB)2670000000057441
  • (SSID)ssj0000448999
  • (PQKBManifestationID)11316065
  • (PQKBTitleCode)TC0000448999
  • (PQKBWorkID)10428225
  • (PQKB)11030992
  • (DE-He213)978-1-60761-744-0
  • (EXLCZ)992670000000057441

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