The Resource Allosteric Regulatory Enzymes, by Thomas W. Traut, (electronic resource)

Allosteric Regulatory Enzymes, by Thomas W. Traut, (electronic resource)

Label
Allosteric Regulatory Enzymes
Title
Allosteric Regulatory Enzymes
Statement of responsibility
by Thomas W. Traut
Creator
Author
Author
Subject
Language
  • eng
  • eng
Summary
All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion-fold. Allosteric enzymes are even more amazing because the have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately dynamic, and responsive, in a changing environment. This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features. While authors often emphasize the few enzymes that have the most remarkable catalytic rates, this survery of enzymes has led to the author's appreciation of some important, general conclusions: 1. Most enzymes are not exceptionally fast; they are always good enough for their specific catalytic step. 2. Although enzymes could always be much faster if they changed so as to bind their substrates more weakly, actual enzymes must be able to discriminate in favor of their special substrate, and therefore they have sacrificed speed to obtain better binding. This means that specific control of individual metabolic steps is more important than overall speed. 3. Results for many hundreds of enzymes establish that a lower limit for a normal catalytic activity is 1 s-1. Most enzymes have a catalytic rate between 10 and 300 s-1. 4. Allosteric regulation always results in a chance in the enzymes's affinity for its substrate. Even V-type enzymes (named for their large chance in catalytic velocity) always have a corresponding change in affinity for their substrate. Thomas Traut has a PhD in molecular biology and has studied enzymes since 1974. As a professor at the University of North Carolina at Chapel Hill, he has focused on enzyme regulation and taught advanced enzymology to graduate students. Important findings from his research helped to define the mechanism of allosteric control for dissociating enzymes.
http://library.link/vocab/creatorName
Traut, Thomas W
Dewey number
  • 572.7
  • 572/.7
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsaut
ppK3N6VhNCU
Language note
English
LC call number
QD431-431.7
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/subjectName
  • Enzymology
  • Biochemistry
  • Biomedical engineering
  • Cell biology
  • Chemistry
  • Medicine
  • Enzymology
  • Biochemistry, general
  • Biomedical Engineering and Bioengineering
  • Cell Biology
  • Chemistry/Food Science, general
  • Biomedicine, general
Label
Allosteric Regulatory Enzymes, by Thomas W. Traut, (electronic resource)
Instantiates
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references (p. 227-239) and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Overview Of Enzymes -- To Enzymes -- The Limits For Life Define The Limits For Enzymes -- Enzyme Kinetics -- Properties And Evolution Of Allosteric Enzymes -- Kinetics Of Allosteric Enzymes -- K-Type Enzymes -- Hemoglobin -- Glycogen Phosphorylase -- Phosphofructokinase -- Ribonucleotide Reductase -- Hexokinase -- V-Type Enzymes -- To V-Type Enzymes -- G Proteins -- Protein Kinases
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (261 p.)
Form of item
online
Isbn
9786611067335
Media category
computer
Media type code
  • c
Other control number
10.1007/978-0-387-72891-9
Specific material designation
remote
System control number
  • (CKB)1000000000404205
  • (EBL)338109
  • (OCoLC)261324851
  • (SSID)ssj0000767985
  • (PQKBManifestationID)12345015
  • (PQKBTitleCode)TC0000767985
  • (PQKBWorkID)10758550
  • (PQKB)10169270
  • (SSID)ssj0000101425
  • (PQKBManifestationID)11127221
  • (PQKBTitleCode)TC0000101425
  • (PQKBWorkID)10042370
  • (PQKB)11101854
  • (DE-He213)978-0-387-72891-9
  • (MiAaPQ)EBC338109
  • (EXLCZ)991000000000404205
Label
Allosteric Regulatory Enzymes, by Thomas W. Traut, (electronic resource)
Publication
Note
Description based upon print version of record
Bibliography note
Includes bibliographical references (p. 227-239) and index
Carrier category
online resource
Carrier category code
  • cr
Content category
text
Content type code
  • txt
Contents
Overview Of Enzymes -- To Enzymes -- The Limits For Life Define The Limits For Enzymes -- Enzyme Kinetics -- Properties And Evolution Of Allosteric Enzymes -- Kinetics Of Allosteric Enzymes -- K-Type Enzymes -- Hemoglobin -- Glycogen Phosphorylase -- Phosphofructokinase -- Ribonucleotide Reductase -- Hexokinase -- V-Type Enzymes -- To V-Type Enzymes -- G Proteins -- Protein Kinases
Dimensions
unknown
Edition
1st ed. 2008.
Extent
1 online resource (261 p.)
Form of item
online
Isbn
9786611067335
Media category
computer
Media type code
  • c
Other control number
10.1007/978-0-387-72891-9
Specific material designation
remote
System control number
  • (CKB)1000000000404205
  • (EBL)338109
  • (OCoLC)261324851
  • (SSID)ssj0000767985
  • (PQKBManifestationID)12345015
  • (PQKBTitleCode)TC0000767985
  • (PQKBWorkID)10758550
  • (PQKB)10169270
  • (SSID)ssj0000101425
  • (PQKBManifestationID)11127221
  • (PQKBTitleCode)TC0000101425
  • (PQKBWorkID)10042370
  • (PQKB)11101854
  • (DE-He213)978-0-387-72891-9
  • (MiAaPQ)EBC338109
  • (EXLCZ)991000000000404205

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