The Resource Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, edited by David D'Argenio, (electronic resource)

Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, edited by David D'Argenio, (electronic resource)

Label
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Title
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Statement of responsibility
edited by David D'Argenio
Creator
Contributor
Editor
Editor
Subject
Language
  • eng
  • eng
Summary
Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/ pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves. The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work
Member of
http://bibfra.me/vocab/relation/corporateauthor
G2nLHW56-Rk
Dewey number
615
http://bibfra.me/vocab/relation/httpidlocgovvocabularyrelatorsedt
M0DM4ix4ZYw
Language note
English
LC call number
RM1-950
Literary form
non fiction
http://bibfra.me/vocab/lite/meetingName
Biomedical Simulations Resource Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
D'Argenio, David.
Series statement
The Springer International Series in Engineering and Computer Science,
Series volume
765
http://library.link/vocab/subjectName
  • Toxicology
  • Statistics
  • Computer industry
  • Biomedical engineering
  • Pharmacology/Toxicology
  • Statistics for Life Sciences, Medicine, Health Sciences
  • The Computing Profession
  • Biomedical Engineering and Bioengineering
Label
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, edited by David D'Argenio, (electronic resource)
Instantiates
Publication
Note
Includes index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Mechanism-Based PK/PD -- Physiological Modeling of the Small Intestine in Drug Absorption -- Intracellular Metabolism of Lamivudine -- Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response -- Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events -- Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies -- Bayesian Inference in Physiologically-based Pharmacokinetic Modeling: Application to Aniticancer Drug Development -- Pharmacometrics -- Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data -- Applications of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD -- Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/Pharmacodynamic Estimation -- Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression -- Pharmacotherapy -- Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients -- Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials -- Dose Individualization for High-dose anti-cancer Chemotherapy -- Toward Model-Based Chemotherapy Treatment Design -- Control of Uncertain Pharmacodynamic Systems
Dimensions
unknown
Edition
1st ed. 2004.
Extent
1 online resource (327 p.)
Form of item
online
Isbn
9781280147661
Media category
computer
Media type code
c
Other control number
10.1007/b105246
Specific material designation
remote
System control number
  • (CKB)1000000000229005
  • (EBL)3036076
  • (SSID)ssj0000097768
  • (PQKBManifestationID)11983798
  • (PQKBTitleCode)TC0000097768
  • (PQKBWorkID)10131933
  • (PQKB)11623464
  • (SSID)ssj0000465342
  • (PQKBManifestationID)11283713
  • (PQKBTitleCode)TC0000465342
  • (PQKBWorkID)10457020
  • (PQKB)11736436
  • (DE-He213)978-0-306-48523-7
  • (MiAaPQ)EBC3036076
  • (EXLCZ)991000000000229005
Label
Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, edited by David D'Argenio, (electronic resource)
Publication
Note
Includes index
Carrier category
online resource
Carrier category code
cr
Content category
text
Content type code
txt
Contents
Mechanism-Based PK/PD -- Physiological Modeling of the Small Intestine in Drug Absorption -- Intracellular Metabolism of Lamivudine -- Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response -- Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events -- Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies -- Bayesian Inference in Physiologically-based Pharmacokinetic Modeling: Application to Aniticancer Drug Development -- Pharmacometrics -- Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data -- Applications of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD -- Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/Pharmacodynamic Estimation -- Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression -- Pharmacotherapy -- Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients -- Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials -- Dose Individualization for High-dose anti-cancer Chemotherapy -- Toward Model-Based Chemotherapy Treatment Design -- Control of Uncertain Pharmacodynamic Systems
Dimensions
unknown
Edition
1st ed. 2004.
Extent
1 online resource (327 p.)
Form of item
online
Isbn
9781280147661
Media category
computer
Media type code
c
Other control number
10.1007/b105246
Specific material designation
remote
System control number
  • (CKB)1000000000229005
  • (EBL)3036076
  • (SSID)ssj0000097768
  • (PQKBManifestationID)11983798
  • (PQKBTitleCode)TC0000097768
  • (PQKBWorkID)10131933
  • (PQKB)11623464
  • (SSID)ssj0000465342
  • (PQKBManifestationID)11283713
  • (PQKBTitleCode)TC0000465342
  • (PQKBWorkID)10457020
  • (PQKB)11736436
  • (DE-He213)978-0-306-48523-7
  • (MiAaPQ)EBC3036076
  • (EXLCZ)991000000000229005

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