The Resource ABC transporters -- 40 years on, Anthony M. George, editor

ABC transporters -- 40 years on, Anthony M. George, editor

Label
ABC transporters -- 40 years on
Title
ABC transporters -- 40 years on
Statement of responsibility
Anthony M. George, editor
Contributor
Editor
Subject
Genre
Language
eng
Summary
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer?s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
Cataloging source
N$T
Dewey number
572/.696
Illustrations
illustrations
Index
no index present
Language note
English
LC call number
QP552.A87
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 55.7
http://library.link/vocab/relatedWorkOrContributorName
George, Anthony M.
http://library.link/vocab/subjectName
  • ATP-binding cassette transporters
  • SCIENCE
  • ATP-binding cassette transporters
  • Life Sciences
  • Membrane Biology
  • Biological and Medical Physics, Biophysics
  • Biochemistry, general
  • Drug Resistance
  • ATP-Binding Cassette Transporters
  • Biophysics
  • Biochemistry
  • Pharmacology
  • Cellular biology (cytology)
Label
ABC transporters -- 40 years on, Anthony M. George, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-23476-2
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
ABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR
Dimensions
unknown
Extent
1 online resource (xiv, 376 pages)
File format
unknown
Form of item
online
Isbn
9783319234762
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-23476-2
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)932464012
  • (OCoLC)ocn932464012
Label
ABC transporters -- 40 years on, Anthony M. George, editor
Link
https://ezproxy.lib.ou.edu/login?url=http://link.springer.com/10.1007/978-3-319-23476-2
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
ABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR
Dimensions
unknown
Extent
1 online resource (xiv, 376 pages)
File format
unknown
Form of item
online
Isbn
9783319234762
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
SpringerLink
Other control number
10.1007/978-3-319-23476-2
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)932464012
  • (OCoLC)ocn932464012

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